{"type":"standard","title":"ACBI3","displaytitle":"ACBI3","namespace":{"id":0,"text":""},"wikibase_item":"Q133278582","titles":{"canonical":"ACBI3","normalized":"ACBI3","display":"ACBI3"},"pageid":79343142,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/7/71/ACBI3_structure.png/330px-ACBI3_structure.png","width":320,"height":109},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/7/71/ACBI3_structure.png","width":1738,"height":592},"lang":"en","dir":"ltr","revision":"1293529233","tid":"34eca0e8-3f79-11f0-b8c2-73ba374c3a1a","timestamp":"2025-06-02T06:17:06Z","description":"Experimental anticancer drug","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/ACBI3","revisions":"https://en.wikipedia.org/wiki/ACBI3?action=history","edit":"https://en.wikipedia.org/wiki/ACBI3?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:ACBI3"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/ACBI3","revisions":"https://en.m.wikipedia.org/wiki/Special:History/ACBI3","edit":"https://en.m.wikipedia.org/wiki/ACBI3?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:ACBI3"}},"extract":"ACBI3 is an experimental anticancer drug which is one of the first examples of a proteolysis targeting chimera or PROTAC. It is a bifunctional molecule with two halves joined by a linker; one half binds to a protein found in various forms of cancer cell called Kirsten rat sarcoma virus or KRAS, while the other half binds E3 ligase which triggers the cell's natural protein degradation mechanisms so that the entire complex is broken down. In early stage testing, it was able to target 13 of the 17 most common mutated forms of KRAS found in cancer cells, allowing selective targeting of a wide range of cancer types. While this particular molecule is still at an early developmental stage and may be unlikely to be approved as a medicine itself, it is an important proof of concept which is likely to lead to the development of a range of related PROTAC type anticancer drugs.","extract_html":"
ACBI3 is an experimental anticancer drug which is one of the first examples of a proteolysis targeting chimera or PROTAC. It is a bifunctional molecule with two halves joined by a linker; one half binds to a protein found in various forms of cancer cell called Kirsten rat sarcoma virus or KRAS, while the other half binds E3 ligase which triggers the cell's natural protein degradation mechanisms so that the entire complex is broken down. In early stage testing, it was able to target 13 of the 17 most common mutated forms of KRAS found in cancer cells, allowing selective targeting of a wide range of cancer types. While this particular molecule is still at an early developmental stage and may be unlikely to be approved as a medicine itself, it is an important proof of concept which is likely to lead to the development of a range of related PROTAC type anticancer drugs.
"}{"fact":"Cats have 300 million neurons; dogs have about 160 million","length":58}
{"slip": { "id": 26, "advice": "Don't cross the streams."}}
{"type":"standard","title":"Gary Buckels","displaytitle":"Gary Buckels","namespace":{"id":0,"text":""},"wikibase_item":"Q5524775","titles":{"canonical":"Gary_Buckels","normalized":"Gary Buckels","display":"Gary Buckels"},"pageid":21971199,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/0/01/1988_Grand_Slam_-_Gary_Buckels_%28cropped%29.jpg/330px-1988_Grand_Slam_-_Gary_Buckels_%28cropped%29.jpg","width":320,"height":414},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/0/01/1988_Grand_Slam_-_Gary_Buckels_%28cropped%29.jpg","width":561,"height":725},"lang":"en","dir":"ltr","revision":"1274739269","tid":"f4d778ae-e678-11ef-acff-7b2efbc083e4","timestamp":"2025-02-09T00:01:05Z","description":"American baseball player (born 1965)","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Gary_Buckels","revisions":"https://en.wikipedia.org/wiki/Gary_Buckels?action=history","edit":"https://en.wikipedia.org/wiki/Gary_Buckels?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Gary_Buckels"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Gary_Buckels","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Gary_Buckels","edit":"https://en.m.wikipedia.org/wiki/Gary_Buckels?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Gary_Buckels"}},"extract":"Gary Scott Buckels is an American former professional baseball pitcher. He played during one season in Major League Baseball (MLB) for the St. Louis Cardinals.","extract_html":"
Gary Scott Buckels is an American former professional baseball pitcher. He played during one season in Major League Baseball (MLB) for the St. Louis Cardinals.
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